Flexible Neural Interfaces Based on 3D PEDOT:PSS Micropillar Arrays

Multi-electrode arrays with 3D micropillars allow the recording of electrophysiological signals in vitro higher precision and signal-to-noise ratio than planar arrays. This is result tight interaction between electrode cell membrane. Most electrodes are manufactured on rigid substrates their integration flexible largely unexplored. Here, a straightforward approach presented for fabricating soft interfaces featuring poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) substrate made polydimethylsiloxane (PDMS). Large-area isotropic PEDOT:PSS tailored geometric area, surface properties, electrochemical characteristics fabricated via combination soft-lithography electrodeposition. A 60% increase capacitance achieved high density compared to this found be correlated increased electroactive area. Furthermore, support adhesion, growth differentiation SH-SY5Y cells, influence direction neurite outgrowth. Finally, by virtue elasticity, act as excellent anchoring loci elongating neurites, facilitating bending twisting around micropillar, increasing number contact points cells electrode, key requirement obtain performance neural interfaces.